Tether influence on the binding properties of tRNA(Lys)(3) ligands designed by a fragment-based approach.
Tether influence on the binding properties of tRNA(Lys)(3) ligands designed by a fragment-based approach. - Related Articles
Tether influence on the binding properties of tRNA(Lys)(3) ligands designed by a fragment-based approach.
Org Biomol Chem. 2010 Mar 7;8(5):1154-9
Authors: Moumné R, Larue V, Seijo B, Lecourt T, Micouin L, Tisné C
A small library of 1,5-triazole derivatives linking a diaminocyclopentadiol and aromatic ketones has been prepared and screened using NMR and fluorescent techniques against tRNA(Lys)(3), the HIV reverse transcription primer. The comparison of their binding properties to those of their 1,4-triazole isomers, previously discovered in a fragment-based approach, outlines the influence of the linker on affinity and binding selectivity in such an approach.
PMID: 20165808 [PubMed - in process] [PubMed-HIV]
